منابع مشابه
Cyclic neutropenia.
Cyclic neutropenia is a rare hematologic disorder, characterized by repetitive episodes of fever, mouth ulcers, and infections attributable to recurrent severe neutropenia. Fluctuations in blood cells are due to oscillatory production of cells by the bone marrow. Recent genetic, molecular, and cellular studies have shown that autosomal-dominant cyclic neutropenia and sporadic cases of this dise...
متن کاملCyclic neutropenia in mammals.
Cyclic neutropenia (CN) has been well documented in humans and the gray collie. A recent model of the architecture and dynamics of hematopoiesis has been used to provide insights into the mechanism of cycling of this disorder. It provides a link between the cycling period and the cells where the mutated ELA2 is expressed. Assuming that the biologic defect in CN is the same in dogs, and the obse...
متن کاملA case report of familial cyclic neutropenia.
A 34-year-old female with cyclic neutropenia is reported. Family studies showed that her three sons and her mother were also involved. Oscillations in the blood neutrophil counts were almost regular, with a periodicity of 21 days. Numbers of colony-forming unit--granulocyte macrophage (CFU-GM) formed from the bone marrow cells of normal volunteers co-cultured with the patient's serum or mononuc...
متن کاملCyclic neutropenia in common variable immunodeficiency.
Detailed studies of patients with so called cyclic neutropenia has revealed involvement of monocytes, lymphocytes, reticulocytes and platelets as well(2). Hence the term cyclic hematopoiesis is more appropriate. These parameters have not been mentioned in the. reported case. There is also no mention of whether the child had organomegaly. This is relevant because patients with cyclic neutropenia...
متن کاملPeriodic hematopoiesis in human cyclic neutropenia.
Human cyclic neutropenia is characterized by severe depression of blood neutrophil levels approximately every 21 days. To investigate the mechanism of cyclic neutropenia four patients were studied with daily complete blood counts, serial bone marrow examinations, marrow reserve testing, serum muramidase determinations, DF(22)P granulocytokinetic studies, and, in one patient, in vivo [(3)H]TdR l...
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ژورنال
عنوان ژورنال: British Dental Journal
سال: 2011
ISSN: 0007-0610,1476-5373
DOI: 10.1038/sj.bdj.2011.151